Colorectal Cancer Modeling
The CISNET Colorectal Working Group (CWG) consists of three modeling groups and a coordinating center. The investigators are focused on the long-term objective of reducing the impact of colorectal cancer (CRC) by providing the information needed to address key policy questions and prioritize future research. The models describe the natural history of colorectal cancer using different underlying structures, which enables model comparisons that explore the impact of structural uncertainty. Despite large increases in screening in the past two decades, colorectal cancer remains the second leading cause of cancer death in the United States. The CWG’s research has shown that more than half of these deaths could be prevented by better use of available screening interventions. In this cycle, the CWG will continue to use microsimulation modeling to evaluate and help prioritize interventions to further reduce the burden of colorectal cancer. The specific aims are:
- Evaluate the impact of screening as practiced in the US
- Inform the debate about the increase in CRC incidence before age 50
- Explore the effectiveness of precision screening and surveillance
- Address other emerging issues and opportunities in CRC control such as genomic biomarkers
- Develop and use high-performance computing methods
Research Highlights
- CISNET Provides Support for Development of Colorectal Cancer Screening Recommendations
- Colorectal Cancer Screening in Adults with Cystic Fibrosis at Increased Risk of CRC
- Effect of Time to Diagnostic Testing for Breast, Cervical, and Colorectal Cancer Screening Abnormalities on Screening Efficacy: A Modeling Study
- Medicare Co-Insurance Loophole: The Value of Waiving Co-Insurance for Medicare Beneficiaries
- Colonoscopy Reduces Risk of Death from Colorectal Cancer in High-Risk Patients
- CMS Reports Cost-Effectiveness of Screening Tests for Colorectal Cancer
- Publications from the Colorectal Working Group