Principal Investigator:
Harry J. De Koning
Institution:
Erasmus Medical Center
Grant Number: 1U01CA115996-01
Awarded under CA-05-018
Abstract: This
application proposes the analysis of trends in prostate cancer incidence and mortality using
a MISCAN prostate cancer model representative of US conditions. The model should combine
evidence obtained in the European randomized study of screening for prostate cancer (ERSPC)
with estimates of prostate cancer epidemiology, intervention efforts and treatment of prostate
cancer in the US.
The model should correctly predict recent trends in incidence and mortality, and quantify the
contributions of prostate-specific antigen (PSA) screening and developments in treatment to
these trends. Moreover the model should quantify the tradeoff between morbidity caused by interventions
like PSA screening or new treatments, and the realized reductions in mortality. Finally the
model will be used to identify optimal screening and treatment strategies.
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