Esophageal Cancer Modeling
The CISNET Esophageal Working Group (EWG) was formed in 2010 in the third round of CISNET funding with three distinct modeling teams focused on collaboratively modeling the incidence and mortality of esophageal adenocarcinoma (EAC) in the US population. The EWG's work in prior funding rounds provides a strong foundation and unique opportunity to assess and improve screening and prevention strategies. In the current funding round, the EWG is evaluating the potential of new screening technologies, prevention methods, genomic and other biomarkers, and clinical prediction tools. Precision risk stratification is being used to identify an effective cancer control strategy that limits overtesting and overtreatment, thereby reducing patient burden and improving healthcare efficiency.
These modeling efforts will provide the personalized patient data necessary to construct decision aids, which will be used to minimize patient screening burden by aligning management choices with personal preferences. In addition, the EWG is broadening its impact by including an esophageal squamous cell carcinoma (ESCC) natural history model and assessing ESCC screening in the US and China. The results from these research efforts will improve our understanding of esophageal cancer and cancer control interventions to diminish the burden of this disease in the US and globally.
- Heberle CR, Omidvari AH, Ali A, Kroep S, Kong CY, Inadomi JM, Rubenstein JH, Tramontano AC, Dowling EC, Hazelton WD, Luebeck EG, Lansdorp-Vogelaar I, Hur C. Cost Effectiveness of Screening Patients With Gastroesophageal Reflux Disease for Barrett's Esophagus With a Minimally Invasive Cell Sampling Device.Clin Gastroenterol Hepatol 2017 Sep;15(9):1397-1404.e7. Epub 2017 Feb 24.
- Kroep S, Heberle CR, Curtius K, Kong CY, Lansdorp-Vogelaar I, Ali A, Wolf WA, Shaheen NJ, Spechler SJ, Rubenstein JH, Nishioka NS, Meltzer SJ, Hazelton WD, van Ballegooijen M, Tramontano AC, Gazelle GS, Luebeck EG, Inadomi JM, Hur C. Radiofrequency Ablation of Barrett's Esophagus Reduces Esophageal Adenocarcinoma Incidence and Mortality in a Comparative Modeling Analysis. Clin Gastroenterol Hepatol2017 Sep;15(9):1471-1474. Epub 2017 Jan 12.
- Kong CY, Kroep S, Curtius K, et al. Exploring the Recent Trend in Esophageal Adenocarcinoma Incidence and Mortality Using Comparative Simulation Modeling. Cancer Epidemiol Biomarkers Prev 2014 June;23(6):997-1006.