Esophageal Cancer Modeling
The CISNET Esophageal Working Group (EWG) was formed in 2010 in the third round of CISNET funding with three distinct modeling teams focused on collaboratively modeling the incidence and mortality of esophageal adenocarcinoma (EAC) in the US population. The EWG's work in prior funding rounds provides a strong foundation and unique opportunity to assess and improve screening and prevention strategies. In the current funding round, the EWG is evaluating the potential of new screening technologies, prevention methods, genomic and other biomarkers, and clinical prediction tools. Precision risk stratification is being used to identify an effective cancer control strategy that limits overtesting and overtreatment, thereby reducing patient burden and improving healthcare efficiency.
These modeling efforts will provide the personalized patient data necessary to construct decision aids, which will be used to minimize patient screening burden by aligning management choices with personal preferences. In addition, the EWG is broadening its impact by including an esophageal squamous cell carcinoma (ESCC) natural history model and assessing ESCC screening in the US and China. The results from these research efforts will improve our understanding of esophageal cancer and cancer control interventions to diminish the burden of this disease in the US and globally.
- Kong CY, Kroep S, Curtius K, et al. Exploring the Recent Trend in Esophageal Adenocarcinoma Incidence and Mortality Using Comparative Simulation Modeling. Cancer Epidemiol Biomarkers Prev 2014 June;23(6):997-1006.
- Hur C, Miller M, Kong CY, Dowling EC, Nattinger KJ, Dunn M, Feuer EJ. Trends in Esophageal Adenocarcinoma Incidence and Mortality. Cancer 2013 Mar 15;119(6):1149-58.
- Hur C, Choi SE, Rubenstein JH, Kong CY, Nishioka NS, Provenzale DT, Inademi JM. The Cost Effectiveness of Radiofrequency Ablation for Barrett’s Esophagus. Gastroenterology 2012 Sep;143(3):567-75.
- Kong CY, Nattinger KJ, Hayeck TJ, et al. The Impact of Obesity on the Rise in Esophageal Adenocarcinoma Incidence: Estimates from a Disease Simulation Model. Cancer Epideiol Biomarkers Prev 2011 Nov;20(11):2450-6.