Breast Cancer Modeling
The CISNET Breast Working Group (BWG) consists of six modeling groups and a coordinating center. The rapid pace of discovery about breast cancer biology has given rise to survival gains and new precision screening and treatment approaches. The BWG is funded to use collaborative computer modeling to inform translation of precision oncology evidence to clinical guidelines and policy by evaluating strategies to further decrease mortality, understand survivor quality of life, and reduce disparities. They will use six breast cancer simulation models as a virtual laboratory to inform policy and clinical decisions by evaluating the impacts on mortality, quality of life, harms, and costs of disseminating these evolving precision cancer control paradigms. The specific aims are:
- Evaluate the impact of novel precision screening approaches;
- Evaluate the impact of precision treatment paradigms in the adjuvant, neo-adjuvant, and metastatic setting;
- Synthesize Aims 1 and 2 to quantify the contributions of precision screening and precision treatment to US breast cancer mortality reductions; and
- Provide evidence to guide interventions to reduce race disparities by quantifying multiple risk, screening, treatment, and survival factors that impact disparities.
- Plevritis SK, Munoz D, Kurian AW, Stout NK, Alagoz O, Near AM, Lee SJ, van den Broek JJ, Huang X, Schechter CB, Sprague BL, Song J, de Koning HJ, Trentham-Dietz A, van Ravesteyn NT, Gangnon R, Chandler Y, Li Y, Xu C, Ergun MA, Huang H, Berry DA, Mandelblatt JS. Association of screening and treatment with breast cancer mortality by molecular subtype in US women, 2000-2012. JAMA 2018 Jan 9;319(2):154-164.
- CISNET Provides Support for Development of Breast Cancer Screening Guidelines
- Publications from the Breast Working Group