Lung Cancer Modeling
The CISNET Lung Working Group (LWG) consists of six modeling groups and a coordinating center. Lung cancer remains the leading cause of cancer related mortality in the US and globally accounting for 1.8 million deaths annually. The CISNET LWG has contributed to the development of US national strategies for reducing the lung cancer burden by quantifying the impact of tobacco control on smoking, lung cancer, and overall mortality, and by evaluating the population benefits and harms of lung cancer screening in the US. In the current funding round, the LWG will extend existing models to assess the impacts of future tobacco control interventions in the ever-changing tobacco market landscape, improvements in lung cancer screening and other emerging early detection strategies, innovations in lung cancer treatment, and their synergistic interactions, on lung cancer rates and overall mortality in the US and globally. The specific aims are:
- Evaluate the impact of current and future tobacco control policies and the adoption of e-cigarettes on smoking rates and lung cancer incidence/mortality, accounting for differences by sociodemographic factors and geographic location.
- Estimate the individual and population impacts of personalized approaches to lung cancer screening and early detection, with consideration for implementation challenges in real-world settings.
- Project the impact of targeted therapies and immunotherapies on US lung cancer mortality.
- Assess the impact of tobacco control strategies on the lung cancer burden in low- and middle-income countries (LMICs)
- CISNET Provides Support for Development of Lung Cancer Screening Recommendations
- Overview of the Tobacco Control Policy Tool
- ten Haaf K, Jeon J, Tammemägi MC, et al. Risk prediction models for selection of lung cancer screening participants: a retrospective validation study. PLoS Medicine 2017; 14(4): e1002277
- Holford TR, Meza R, Warner KE et al. Tobacco Control and the Reduction in Smoking-Related Premature Deaths in the United States, 1964-2012. JAMA. 2014;311(2):164-171
- de Koning HJ, Meza R, Plevritis SK, et al. Benefits and Harms of Computed Tomography Lung Cancer Screening Strategies: A Comparative Modeling Study for the U.S. Preventive Services Task Force. Ann Intern Med, 2013
- Holford TR, Levy DT, McKay LA, et al. Patterns of Birth CohortSpecific Smoking Histories, 19652009. Am J Prev Med 2014;46(2)
- Impact of Reduced Tobacco Smoking on Lung Cancer Mortality in the United States During 1975-2000
- Lung Cancer Model Applied to Michigan and Kentucky to Measure Impact of Tobacco Control Policies
- Publications from the Lung Working Group
- CISNET Provides Support for Development of Lung Cancer Screening Guidelines