Bladder Cancer
The CISNET Bladder Working Group, funded as a CISNET Incubator Program cancer site, comprises two modeling groups and a coordinating center. The investigators are focused on completing the development, calibration and validation of two independent population models of bladder cancer and will address questions on its prevention, diagnosis, treatment, and surveillance by means of comparative mathematical modeling.
Investigators
Population Modeling of Bladder Cancer Detection and Control
Grant Number: U01CA265750
Abstract & Aims
Abstract: Bladder cancer is the second most common genitourinary malignancy in the US with approximately 80,000 new cases and 17,700 deaths each year. It is a heterogeneous set of diseases that range from locally treatable superficial tumors that are generally not life-threatening but require chronic management, to advanced disease that requires multimodal invasive treatments and has higher risk of distal metastasis and death. It is the ninth most expensive cancer overall in the US, and, per diagnosed patient, the most expensive cancer to manage. Risk factors for bladder cancer broadly include chemical and environmental exposures such as cigarette smoking and chemical carcinogens that are ingested or found in the workplace, as well as genetic abnormalities and chronic bladder irritation. Outcomes for bladder cancer have remained relatively stable in the last two decades. However, opportunities abound to improve the prevention, detection, and management of bladder cancer. The advent of novel biomarkers, and novel treatments, including immunotherapies (checkpoint inhibitors), gene therapies, and antibody-drug conjugates may have a large impact in coming years.
Bladder cancer is amenable to population modeling because it has high morbidity, mortality, and cost, is likely preventable by minimizing smoking and toxin exposure, and the emergence of novel promising biomarkers and treatments. The long-term goal of our research program is to improve the effectiveness and efficiency of population- and person-level approaches to bladder cancer prevention, detection, and management given current knowledge and constraints. The overall objective of the current proposal is to address major questions in the surveillance, treatment, prevention, and diagnosis of bladder cancer by means of comparative mathematical modeling.
The specific aims are to:
- Develop, calibrate, and validate two independent population models of bladder cancer;
- Explain secular trends in bladder cancer incidence in relation to trends in tobacco use in key population subgroups and estimate the impact of the 1964 Surgeon General’s smoking recommendations;
- Assess the effectiveness of smoking cessation, reduction and prevention interventions for the prevention of bladder cancer incidence and mortality;
- Assess the effectiveness and cost-effectiveness of generic and tailored/patient-centric surveillance policies for patients with non-muscle invasive bladder cancer;
- Assess the comparative effectiveness of treatments for organ-confined bladder cancer; and
- Assess the effectiveness of screening for bladder cancer among high-risk subgroups.
Model Profiles & Registry
Model profiles are standardized documents that facilitate the comparison of models and their results. The Joint Profile provided includes profiles for all bladder cancer models. Individual profiles for each model are also provided and may be more current than the joint profile document.
The following model profiles have been developed by CISNET members for bladder cancer:
Model Comparison Grid (PDF, 145 KB)
Individual Models
- Kystis (Brown) In progress
- Cobras (Ottawa) In progress
- SCOUT (NYU) In progress
Historical Versions
Historical versions of model profiles and grids will be listed here.
For additional high-level information about the bladder models visit the bladder overview page on the CISNET Model Registry.